Research Director at Filament Health discusses the future of psychedelics

During the AMA, industry professionals and psychedelic fans had the opportunity to ask Moss questions for several hours. Moss has over a decade of experience in the mining and production of psychoactive mushrooms, including his current position at Filament Health.

What surprised you the most about your research?

I am truly amazed at the sheer number of varieties and even individual species of psilocybin-containing mushrooms that have been propagated by pioneering mycologists, hobbyists, and others interested in breeding these organisms.

In my research, we only touched the surface (about 20 fully cultivated varieties now and many more in the future!), But the differences in psilocybin content between the two can be huge. Not only that, but the differences in where psilocybin bioaccumulates in the fruiting body is also highly cultivar-dependent! (think “caps” versus “stems”).

Do different compounds produce different effects, or is it the same active ingredient, psilocybin?

The main active ingredient causing the high is psilocybin and its active metabolite psilocin. In your body, the psilocybin you consume is metabolized into psilocin, which can attach to receptors in your brain. Mushrooms produce psilocybin, but some of it can degrade to psilocin while in mushrooms (blue coloration).

So, when you eat dried mushroom, the balance of psilocybin and its metabolite could potentially have some effect on the “surge”, but this system of activity is relatively the same for MOST varieties of magic mushrooms.

Now, different varieties can have huge differences in psilocybin content. In my research, we have completely bred about 20 varieties and several different species (not just psilocybians). Some of these varieties can even be 5-10 times more potent than their counterparts.

On top of that, the stems and caps of different species bioaccumulate psilocybin and psilocin in varying proportions! All this means that a huge amount of research needs to be done only in relation to the subjective effects that some of these parameters have.

Another important factor in this study is the halo effect. Although we are aware of many other alkaloids present in fungi (norbaeocystin, baeocystin, aeruginascin, norpsilocin, etc.) in low content. Do these connections alter subjective perception? enhance? to brake? We don’t know, and that’s a huge part of what my research is focused on.

I will say that another important aspect of this is that since mushrooms vary in psychoactive alkaloids, species to species, variety to variety, harvest to harvest, and even wash to wash, you cannot give yourself a known dose. psilocybin using raw magic mushrooms.

The only way to do this is through extraction, standardization, and proper dosing. This is what is needed for these compounds to become a suitable medicine.

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